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  1. Despite the notable success of cancer immunotherapy, its effectiveness is often limited in a significant proportion of patients, highlighting the need to explore alternative tumor immune evasion mechanisms. Ad...

    Authors: Yuying Yang, Lin Zhu, Yantao Xu, Long Liang, Li Liu, Xiang Chen, Hui Li and Hong Liu
    Citation: Biomarker Research 2025 13:75
    Content type: Review Published on:

  2. Lung cancer remains the leading cause of cancer-related deaths worldwide. Low-dose computed tomography (LD-CT) screening, combined with effective minimally invasive molecular testing such circulating microRNA,...

    Authors: Elisa Dama, Tommaso Colangelo, Roberto Cuttano, Rafal Dziadziuszko, Thomas Dandekar, Piotr Widlak, Witold Rzyman, Giulia Veronesi and Fabrizio Bianchi
    Citation: Biomarker Research 2025 13:74
    Content type: Correspondence Published on:

  3. Acute myeloid leukemia (AML) with KMT2A rearrangements (KMT2A-r) represents a highly aggressive and prognostically unfavorable subtype of leukemia, often resistant to standard treatments and associated with hi...

    Authors: Sara Zehtabcheh, Hamed Soleimani Samarkhazan, Marjan Asadi, Mitra Zabihi, Sahar Parkhideh and Mohammad Hossein Mohammadi
    Citation: Biomarker Research 2025 13:73
    Content type: Review Published on:

  4. Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory disease of the bladder for which no effective therapy is currently available. Understanding the pathogenesis of IC/BPS and identif...

    Authors: Jiang Zhao, Mi Zhou, Chengfei Yang, Yang-Wuyue Liu, Teng Yang, Bishao Sun, Benyi Li, Ji Zheng, Shuangshuang Dai, Zhenxing Yang and Xiangwei Wang
    Citation: Biomarker Research 2025 13:72
    Content type: Research Published on:

  5. Diagnosing primary or secondary CNS lymphoma (CNSL) is a clinical challenge due to the limitations of standard biopsy and imaging procedures despite established guidelines. Therefore, accurate biomarkers and a...

    Authors: Veronika Navrkalova, Andrea Mareckova, Samuel Hricko, Viera Hrabcakova, Lenka Radova, Vaclav Kubes, Jakub Porc, Tomas Reigl, Sarka Pospisilova, Jana Kotaskova and Andrea Janikova
    Citation: Biomarker Research 2025 13:71
    Content type: Research Published on:

  6. Progesterone and adipose Q receptor 5 (PAQR5), a membrane receptor characterized by seven transmembrane domains, has been indirectly implicated in pro-carcinogenic activities, though its specific role in hepat...

    Authors: Ruida Yang, Huanhuan Wang, Cong Wu, Yu Shi, Hanqi Li, Xinyue Bao, Yuqian Yang, Shaoshan Han, Xue Yang, Jie Tao, Hao Sun, Shaobo Wu and Liankang Sun
    Citation: Biomarker Research 2025 13:70
    Content type: Research Published on:

  7. Head and neck squamous cell carcinoma (HNSCC) remains among the most aggressive malignancies with limited treatment options, especially in recurrent and metastatic cases. Despite advances in surgery, radiother...

    Authors: Sahand Saeidpour Masouleh, Kamyar Nasiri, Ava Ostovar Ravari, Mona Saligheh Rad, Kiarash kiani, Ali Sharifi Sultani, Seyedeh Tabasom Nejati and Mohsen Nabi Afjadi
    Citation: Biomarker Research 2025 13:69
    Content type: Review Published on:

  8. The C-X-C chemokine receptor type 4 (CXCR4) has emerged as a key molecular biomarker for cancer therapies due to its critical role in tumor progression and metastases by displaying a stem cells phenotype. Its ...

    Authors: Ariana Rueda, Naroa Serna, Ramon Mangues, Antonio Villaverde and Ugutz Unzueta
    Citation: Biomarker Research 2025 13:68
    Content type: Review Published on:

  9. Biomarker profiling from biofluids such as blood are widely measured in clinical research, using for example Olink proteomics panels. One such research focus area is cardiovascular disease (CVD), for which chr...

    Authors: Luiz Eduardo Mateus Brandão, Lei Zhang, Anastasia Grip, Mun-Gwan Hong, Emil Kåks, Rui Benfeitas, Fjola Sigurdardottir, Kaj Blennow, Henrik Zetterberg, Daniel Espes, Torbjørn Omland, Payam Emami Khoonsari, Christian Benedict and Jonathan Cedernaes
    Citation: Biomarker Research 2025 13:67
    Content type: Correspondence Published on:

  10. Authors: Kyung Taek Hong, Sungyeun Bae, Yoon Sunwoo, Juyeon Lee, Hyun Jin Park, Bo Kyung Kim, Jung Yoon Choi, Joo-Youn Cho, Kyung-Sang Yu, Jaeseong Oh and Hyoung Jin Kang
    Citation: Biomarker Research 2025 13:66
    Content type: Correction Published on:

    The original article was published in Biomarker Research 2025 13:48

  12. While the advent of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of relapsed or refractory DLBCL, it is unclear how survival has changed at the population level following i...

    Authors: John L. Vaughn, Angela Ramdhanny, Malak Munir, Sravani Rimmalapudi and Narendranath Epperla
    Citation: Biomarker Research 2025 13:64
    Content type: Correspondence Published on:

  13. Huntington disease (HD) is a progressive and devastating neurodegenerative disease caused by expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene above a critical threshold of ~ 35 repeats resul...

    Authors: Rachel J. Harding, Yuanyun Xie, Nicholas S. Caron, Hailey Findlay-Black, Caroline Lyu, Nalini Potluri, Renu Chandrasekaran, Michael R. Hayden, Blair R. Leavitt, Douglas R. Langbehn and Amber L. Southwell
    Citation: Biomarker Research 2025 13:63
    Content type: Research Published on:

  14. Angiogenesis, a crucial process in tumor growth and metastasis, necessitates targeted therapeutic intervention. This review reviews the latest knowledge of anti-angiogenesis targets in tumors, with emphasis on...

    Authors: Xueru Liu, Juan Zhang, Ting Yi, Hui Li, Xing Tang, Dan Liu, Daichao Wu and Yukun Li
    Citation: Biomarker Research 2025 13:62
    Content type: Review Published on:

  15. Surface antigens of potential clinical significance remain under-characterized in AML. The European Leukemia Network classifies normal karyotype AML (NK-AML) mutated for NPM1 (NPM1c) as a distinct entity assoc...

    Authors: Arnaud Métois, Marie-Eve Bordeleau, Louis Theret, Azadeh Hajmirza, Ossama Moujaber, Jean-François Spinella, Jalila Chagraoui, Nadine Mayotte, Isabel Boivin, Éric Audemard, Léo Aubert, Véronique Lisi, Banafsheh Khakipoor, Azer Farah, Éric Bonneil, Alma Robert…
    Citation: Biomarker Research 2025 13:61
    Content type: Research Published on:

  16. Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers. With the approval of multiple first- and second-line agents, especially the combination therapies based on immune checkpo...

    Authors: Xinyu Guo, Zhongwei Zhao, Lingyi Zhu, Shuang Liu, Lingling Zhou, Fazong Wu, Shiji Fang, Minjiang Chen, Liyun Zheng and Jiansong Ji
    Citation: Biomarker Research 2025 13:60
    Content type: Review Published on:

  18. Remarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and a cell lysis phase, the...

    Authors: Rui Miao, Xueying Wang, Jingyv Zhang, Qinyv Kang, Qing Liu, Xianglin Luo, Junwei Hou and Baorong Gao
    Citation: Biomarker Research 2025 13:58
    Content type: Review Published on:

    The Correction to this article has been published in Biomarker Research 2025 13:65

  19. Maintaining protein homeostasis is vital for multiple myeloma (MM) cell survival. Indirubin- 3-monoxime (I3MO), a potential MM therapeutic, inhibits proteasome activity, while histone deacetylase 6 (HDAC6) reg...

    Authors: Teng Fang, Lanting Liu, Hao Sun, Xiaoyu Zhang, Xiyue Sun, Zhen Yu, Lixin Gong, Shiyi Xie, Yonglong Zhao, Yan Li, Lugui Qiu, Gang An, Bin He and Mu Hao
    Citation: Biomarker Research 2025 13:57
    Content type: Research Published on:

  20. Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder characterized by systematic inflammatory symptoms and multiorgan dysfunction caused by a cytokine storm. The current asse...

    Authors: Miao-yan Zhang, Zi-han Yang, Yu-chong Qiu, Yu-han Gao, Si-yuan Li, Yue Dang, Lu Zhang and Jian Li
    Citation: Biomarker Research 2025 13:56
    Content type: Correspondence Published on:

  21. Hypertrophic cardiomyopathy (HCM) is the common cause of sudden cardiac death in young people and is characterized by cardiac hypertrophy. Non-HCM caused left ventricular hypertrophy (LVH) is more common in th...

    Authors: Hao Cui, Yifan Wang, Xiumeng Hua, Jing Han, Han Mo, Shun Liu, Hongmei Wang, Siyuan Huang, Yiqi Zhao, Xiao Chen, Qian Zhao, Hao Jia, Yuan Chang and Jiangping Song
    Citation: Biomarker Research 2025 13:55
    Content type: Correspondence Published on:

  22. Pancreatic adenocarcinoma (PAAD) is a highly lethal malignancy that leads to patients missing optimal treatment opportunities due to its atypical clinical symptoms and the lack of effective diagnostic biomarke...

    Authors: Yueting Liang, Xin Sui, Shuai Li, Haoxin Peng, Wenyi Jiang, Minqi Jia, Shaoran Jiang, Weihu Wang and Huajing Teng
    Citation: Biomarker Research 2025 13:54
    Content type: Correspondence Published on:

  23. Cardiac hypertrophy, a leading cause of heart failure, threatens global public health. Deubiquitinating enzymes (DUBs) are critical in cardiac pathophysiology by regulating protein stability, function, and deg...

    Authors: Rujie Zheng, Wenjuan Song, Che Wang, Xiaoyu Du, Chunlei Liu, Xiaotong Sun and Chengzhi Lu
    Citation: Biomarker Research 2025 13:53
    Content type: Research Published on:

  24. Antibodies play a crucial role in defending the human body against diseases, including life-threatening conditions like cancer. They mediate immune responses against foreign antigens and, in some cases, self-a...

    Authors: Varun Dewaker, Vivek Kumar Morya, Yoo Hee Kim, Sung Taek Park, Hyeong Su Kim and Young Ho Koh
    Citation: Biomarker Research 2025 13:52
    Content type: Review Published on:

  26. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a primary first-line treatment for type 2 diabetes. This has raised concerns about their impact on cancer risk, spurring extensive research....

    Authors: Anqi Lin, Yanxi Ding, Zhengrui Li, Aimin Jiang, Zaoqu Liu, Hank Z. H. Wong, Quan Cheng, Jian Zhang and Peng Luo
    Citation: Biomarker Research 2025 13:50
    Content type: Review Published on:

  27. Galectins play pivotal roles in cellular recognition and signaling processes by interacting with glycoconjugates. Extensive research has highlighted the significance of Galectins in the context of cancer, aidi...

    Authors: Nan Zhang, Qiao Liu, Daihan Wang, Xiaoyun Wang, Zhaoping Pan, Bo Han and Gu He
    Citation: Biomarker Research 2025 13:49
    Content type: Review Published on:

  28. Post-transplantation cyclophosphamide (PTCy) has paved the way for the increased use of alternative donors, including haploidentical familial donors, with acceptable engraftment and graft-versus-host disease (...

    Authors: Kyung Taek Hong, Sungyeun Bae, Yoon Sunwoo, Juyeon Lee, Hyun Jin Park, Bo Kyung Kim, Jung Yoon Choi, Joo-Youn Cho, Kyung-Sang Yu, Jaeseong Oh and Hyoung Jin Kang
    Citation: Biomarker Research 2025 13:48
    Content type: Research Published on:

    The Correction to this article has been published in Biomarker Research 2025 13:66

  29. To provide insights into rheumatoid arthritis (RA) epidemiological trends, including prevalence, incidence, disability-adjusted life years (DALYs), corresponding average annual percentage change (AAPC), gender...

    Authors: Yingnan Ma, Haiyan Chen, Wenhua Lv, Siyu Wei, Yuping Zou, Ruilin Li, Jiacheng Wang, Wei She, Linna Yuan, Junxian Tao, Xuying Guo, Shuo Bi, Hongsheng Tian, Ye Ma, Hongmei Sun, Chen Sun…
    Citation: Biomarker Research 2025 13:47
    Content type: Research Published on:

  30. Bone changes in patients undergoing pelvic radiotherapy remain unclear. This study initially utilized high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess the dynamic changes in bone...

    Authors: Weishi Cheng, Yijun Wu, Jing Shen, Hui Guan, Li Zhang, Hongnan Zhen, Yinjie Tao, Weibo Xia, Zhikai Liu and Fuquan Zhang
    Citation: Biomarker Research 2025 13:46
    Content type: Correspondence Published on:

  31. Artificial intelligence (AI) can transform drug discovery and early drug development by addressing inefficiencies in traditional methods, which often face high costs, long timelines, and low success rates. In ...

    Authors: Alberto Ocana, Atanasio Pandiella, Cristian Privat, Iván Bravo, Miguel Luengo-Oroz, Eitan Amir and Balazs Gyorffy
    Citation: Biomarker Research 2025 13:45
    Content type: Review Published on:

  32. Tumor immune evasion extends beyond T cells, affecting innate immune elements like natural killer cells (NK) and macrophages within the tumor-immune microenvironment (TIME). Nevertheless, translational strateg...

    Authors: Zhouwenli Meng, Jian Li, Hui Wang, Zhengqi Cao, Wenqing Lu, Xiaomin Niu, Yi Yang, Ziming Li, Ying Wang and Shun Lu
    Citation: Biomarker Research 2025 13:44
    Content type: Research Published on:

  34. Fatty acids serve as a crucial energy source for tumor cells during the progression of chronic lymphocytic leukemia (CLL). The present study aims to elucidate the characteristics of fatty acid metabolism (FAM)...

    Authors: Yang Zhang, Jun Ma, Peipei Li, Kang Lu, Yang Han, Xinting Hu, Xiaosheng Fang, Xin Wang and Ya Zhang
    Citation: Biomarker Research 2025 13:42
    Content type: Research Published on:

  37. Developing accurate, clinically convenient, and non-invasive methods for early cancer detection, monitoring, and prognosis assessment is essential for improving patient survival rates, enhancing quality of lif...

    Authors: Danjun Song, Zhou Zhang, Jiaping Zheng, Wei Zhang and Jiabin Cai
    Citation: Biomarker Research 2025 13:39
    Content type: Review Published on:

  38. The tumour microenvironment is the “hotbed” of tumour cells, providing abundant extracellular support for growth and metastasis. However, the tumour microenvironment is not static and is constantly remodelled ...

    Authors: Zonghao Liu, Xiaofang Zhang, Tianru Ben, Mo Li, Yi Jin, Tianlu Wang and Yingqiu Song
    Citation: Biomarker Research 2025 13:38
    Content type: Review Published on:

  39. Hepatocellular carcinoma (HCC) can be classified into several subtypes based on molecular traits, aiding in prognostic stratification. The subtype with a poor prognosis is often associated with stem/progenitor...

    Authors: Yuto Shiode, Takahiro Kodama, Yu Sato, Ryo Takahashi, Takayuki Matsumae, Kumiko Shirai, Akira Doi, Yuki Tahata, Hayato Hikita, Tomohide Tatsumi, Moto Fukai, Akinobu Taketomi, Mathuros Ruchirawat, Xin Wei Wang and Tetsuo Takehara
    Citation: Biomarker Research 2025 13:37
    Content type: Research Published on:

  40. Studies have indicated that X-linked microRNAs (miRNAs) play a role in the pathogenesis of rheumatoid arthritis (RA) and its gender-specific differences. However, research on specific miRNAs remains limited. T...

    Authors: Jiu Jie Yang, Zhi Li, Lin Na Wang, Bai Xiong Huang, Jerome P. L. Ng, Xiong Fei Xu, Yu Ping Wang, David Wei Zhang, Bo Qin, Ding Qi Zhang, Chang Liu, Wei Dan Luo, Betty Yuen Kwan Law, Hui Miao Wang, Meng Han Liu, Xiao Yun Yun…
    Citation: Biomarker Research 2025 13:36
    Content type: Research Published on:

  41. The battle against cancer has evolved over centuries, from the early stages of surgical resection to contemporary treatments including chemotherapy, radiation, targeted therapies, and immunotherapies. Despite ...

    Authors: Fei Du, Guojun Wang, Qian Dai, Jiang Huang, Junxin Li, Congxing Liu, Ke Du, Hua Tian, Qiwei Deng, Longxiang Xie, Xin Zhao, Qimin Zhang, Lan Yang, Yaling Li, Zhigui Wu and Zhuo Zhang
    Citation: Biomarker Research 2025 13:35
    Content type: Review Published on:

  42. Assessment of adult T-cell leukemia/lymphoma (ATL) development among human T-lymphotropic virus 1 (HTLV-1)-infected individuals (carriers) constitute a significant issue. A high HTLV-1 proviral load (PVL) in c...

    Authors: Koji Jimbo, Masanori Nojima, Keiko Toriuchi, Makoto Yamagishi, Makoto Nakashima, Yoshihisa Yamano, Kaoru Uchimaru and Yasuhito Nannya
    Citation: Biomarker Research 2025 13:34
    Content type: Research Published on:

  43. Ligamentum flavum hypertrophy (LFH) is a primary contributor to lumbar spinal stenosis. However, a thorough understanding of the cellular and molecular mechanisms driving LFH fibrotic progression remains incom...

    Authors: Chengshuo Fei, Yanlin Chen, Ruiqian Tan, Xinxing Yang, Guanda Wu, Chenglong Li, Jiawei Shi, Shiyong Le, Wenjie Yang, Jiajia Xu, Liang Wang and Zhongmin Zhang
    Citation: Biomarker Research 2025 13:33
    Content type: Research Published on:

  44. The discovery of Toll-like receptors (TLRs) and their role in dendritic cells earned the Nobel Prize for 2011 because TLRs profoundly enhanced our understanding of the immune system. Specifically, TLR3 is loca...

    Authors: Marvin L Hsieh, Daisuke Nishizaki, Jacob J Adashek, Shumei Kato and Razelle Kurzrock
    Citation: Biomarker Research 2025 13:32
    Content type: Review Published on:

  45. The use of poly(ADP-ribose) polymerase inhibitors (PARPi) revolutionized the treatment of BRCA-mutated cancers. Identifying patients exhibiting homologous recombination deficiency (HRD) has been proved useful to ...

    Authors: Andréa Witz, Julie Dardare, Margaux Betz, Cassandra Michel, Marie Husson, Pauline Gilson, Jean-Louis Merlin and Alexandre Harlé
    Citation: Biomarker Research 2025 13:31
    Content type: Review Published on:

  46. Early detection of colorectal cancer (CRC) significantly improves its management and patients’ survival. Circular RNAs (circRNAs) are peculiar covalently closed transcripts involved in gene expression modulati...

    Authors: Alessandro Camandona, Amedeo Gagliardi, Nicola Licheri, Sonia Tarallo, Giulia Francescato, Eva Budinska, Martina Carnogurska, Barbora Zwinsová, Barbara Martinoglio, Lorenzo Franchitti, Gaetano Gallo, Santina Cutrupi, Michele De Bortoli, Barbara Pardini, Alessio Naccarati and Giulio Ferrero
    Citation: Biomarker Research 2025 13:30
    Content type: Research Published on:

  47. Authors: Xin-Yi Sui, Shuo-Wen Cao, Xiao-Qing Song, Xi-Yu Liu, Chao Chen, Qingya Yan, Zhi-Qing Wang, Wen-Juan Zhang, Lin-Xiaoxi Ma, Xi Jin, Ding Ma, Yi Xiao, Song-Yang Wu, Ying Xu, Zhi-Ming Shao and Lei Fan
    Citation: Biomarker Research 2025 13:29
    Content type: Correction Published on:

    The original article was published in Biomarker Research 2025 13:6

  48. Acute myeloid leukemia (AML) remains a formidable blood cancer, despite recent advances in treatment. A significant challenge persists in improving patient outcomes, particularly in addressing relapse and trea...

    Authors: Hamed Soleimani Samarkhazan, Sara Zehtabcheh, Hamideh Rahmani Seraji, Safedin H. Beqaj, Shamim Tayefeh, Mohammad Hossein Mohammadi and Mojtaba Aghaei
    Citation: Biomarker Research 2025 13:28
    Content type: Review Published on:

  49. Platelets, anucleate blood cells essential for hemostasis, are increasingly recognized for their role in cancer, challenging the traditional notion of their sole involvement in blood coagulation. It has been d...

    Authors: Miguel Morales-Pacheco, Miguel Valenzuela-Mayen, Angel M. Gonzalez-Alatriste, Gretel Mendoza-Almanza, Sergio A. Cortés-Ramírez, Alberto Losada-García, Griselda Rodríguez-Martínez, Imelda González-Ramírez, Vilma Maldonado-Lagunas, Karla Vazquez-Santillan, Vanessa González-Covarrubias, Carlos Pérez-Plasencia and Mauricio Rodríguez-Dorantes
    Citation: Biomarker Research 2025 13:27
    Content type: Review Published on:

  50. Osteoarthritis (OA), a ubiquitous degenerative joint disorder, is marked by pain and disability, profoundly impacting patients' quality of life. As the population ages, the global prevalence of OA is escalatin...

    Authors: Yuanyuan Wei, He Qian, Xiaoyu Zhang, Jian Wang, Heguo Yan, Niqin Xiao, Sanjin Zeng, Bingbing Chen, Qianqian Yang, Hongting Lu, Jing Xie, Zhaohu Xie, Dongdong Qin and Zhaofu Li
    Citation: Biomarker Research 2025 13:26
    Content type: Review Published on:
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    Journal Impact Factor: 9.5
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Biomarker Research

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